Catch-up growth after dexamethasone withdrawal occurs in cultured postnatal rat metatarsal bones

Catch-up growth occurs after diarrhea in early childhood.

Diarrhea and linear growth faltering continue to burden low-income countries and are among the most important contributors to poor health during early childhood. Diarrhea is thought to adversely affect linear growth, but catch-up growth can occur if no additional insults are experienced. We sought to characterize catch-up growth in relation to diarrhea burden in a multisite dataset of 1007 chil...

Congenital Hypothyroidism: Effects on Linear Growth, Catch-Up Growth, GH-IGF-I Axis and Bones

Triiodothyronine (T3) is a primary determinant of normal postnatal somatic growth and skeletal development, and an important regulator of bone and mineral metabolism in hu‐ man [1, 2]. Before puberty, thyroid hormone appears to be a major prerequisite for normal maturation of bone [3]. Untreated childhood hypothyroidism results in a profound growth retardation and a delayed skeletal maturation....

Catch-up Growth

Catch-up growth.

Catch-up growth, defined as growth velocity above the statistical limits of normality for age or maturity during a defined period of time, is distinguished from compensatory growth since it makes up for a potential loss rather than an actual loss and is seen in the whole body as opposed to specific organs. The cellular explanation for catch-up based on the work of Winick is described and a rece...

Characterization of apoptosis in cultured rat sympathetic neurons after nerve growth factor withdrawal

Sympathetic neurons depend on nerve growth factor (NGF) for their survival both in vivo and in vitro. In culture, the neurons die after NGF withdrawal by an autonomous cell death program but whether these neurons die by apoptosis is under debate. Using vital DNA stains and in situ nick translation, we show here that extensive chromatin condensation and DNA fragmentation occur before plasma memb...